Scientists re-grow amputated legs of frogs .. Does the process work with humans?

Using Bio-Dome shortly after amputation would place the wound in a sterile environment, mimicking the amniotic fluid that allows the fetus to develop in the mother’s womb.

Life sometimes works miracles, returning a missing tail to a lizard or a claw to a paralyzed crab. On the other hand, regeneration of a missing leg in mammals is a priori impossible. But can this situation change?

Author Gael Lombart answers this question in Article Which was published by the French newspaper “Le Parisien” on January 27, through search Published by “Science Advances” magazine.

The new limbs were fully functional and allowed the frogs to swim like everyone else again (pixels)

Growing amputated legs

Lombart says that scientists from Tufts University in Boston and Harvard University’s Wyss Institute have succeeded in regrowth of amputated legs from a group of frogs, raising hopes of doing the same with mammals, and specifically with humans.

The writer states that the process that was used was very simple; Where the researchers applied a mixture of 5 drugs to the wounds for 24 hours by encapsulating them with a silicone cover called “Bio Dome.” After this short treatment, the upper part of the legs grew again after 18 months, and the research team confirmed that the new limbs were fully functional and allowed the frogs Swimming like everyone else again.

The author quotes Nerusha Murugan, the study’s lead author, as confirming that the treated animal had intentional movement and was responding to the lightest tactile stimulation, while the untreated animals did not respond to any level of tactile stimulation, indicating that the animals treated with the drug regained the growth of their nerves and connections. Kinetic.

Soft Xenopus Frog African Clawed Frog (Pixels)

non-random choice

The author explains that the amphibians used in the experiment were not chosen randomly; The soft xylem frog – an African clawed frog – like humans loses its ability to regenerate as it grows.

A biologist at Tufts University says – according to the author – “Frogs move from being completely renewable, when they are in the tadpole stage, to being completely non-renewable like adults, and this is similar to humans, early in our development process, in the embryonic stage and in the early years what After birth, humans have some ability to regenerate but lose it completely in adulthood.”

Lombart shows that normally, large injuries to the legs or arms are quickly covered with skin cells to protect the individual from blood loss or infection, which prevents the limbs from regrowth.

Using Bio-Dome shortly after amputation would place the wound in a sterile environment (Pixels)

On the contrary, the writer adds; The use of “Bio-Dome” shortly after the amputation would place the wound in a sterile environment, in a way that simulates the amniotic fluid that allows the fetus to grow in the mother’s womb; “The idea in a nutshell is to control the first events, when cells first decide what to do,” says Michael Levine, co-author of the study.

In response to a question about the contribution of this achievement to opening the horizons of human medicine; Nerosha Murugan replied – according to the author – that the process is scalable with the aim of using it on humans, noting that experiments will first be conducted on smaller mammals. As Michael Levine also commented on the topic, “We’re certainly not ready for human testing, but I think it’s an important step on the way toward potential clinical application.”

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